Letrozole (the most popular brand name – Femara) is an extremely powerful aromatase inhibitor (AI). This is an oral drug that in medical settings is popular for the treatment of hormonally responsive breast cancer after surgery. Therefore, this drug is still having FDA approval to use in post menopausal women that are suffering from hormonal receptor positive types of breast cancer.
Although it is banned in some parts of the world, most countries still have it, but only as a prescription drug. Bodybuilders, however, found it effective for their needs too. If you’re familiar with aromatase inhibitors (AI) then you already understand how bodybuilders use them.
Other Letrozole Uses
Letrozole (Femara) is popular as a medication that is treating female breast cancer that is estrogen positive and that’s typical of all other Aromatase Inhibitors (AIs) out there. However, it has some other uses too, either off label or as prescribed.
For example, some use it as a fertility drug because Femara could stimulate ovaries in women.
Another thing to mention is that it could stack with other drugs for early pregnancy termination (due to powerful anti-estrogen properties).
Another thing is that stacking with Growth Hormones, it could help adolescent boys grow taller.
Moreover, it could even help promote spermatogenesis in males too (boosts sperm count).
One more thing to mention – it can treat gynecomastia. It does it extremely efficiently.
In fact, that’s the most popular use of Letrozole in bodybuilding settings, for treating gynecomastia. In fact, a lot of steroid users classify Letrozole as the most powerful aromatase inhibitor, so it is often used as a last resort drug when all other versions of AIs fail to help deal with gynecomastia or other high estrogenic issues.
How Does Letrozole Work?
Letrozole is working in very exact same ways as all other aromatase inhibitors (AIs). It works by binding to the aromatase enzyme. This ensures that estrogen is not going to be released. However, this is a type II aromatase inhibitor – it’s extremely powerful.
Letrozole works by binding to aromatase enzymes disabling them, thus lowering total estrogen levels in the body. But since it is extremely powerful (the most powerful AI on the market), Femara could decrease the estrogen levels in women up to an incredible 98%! There are also studies done on men using Letrozole too, and they indicate that men using Femara would have an extremely fast and dramatic reduction in estrogen levels too.
It’s so effective because of its ability to crush estrogen through the reversible binding to the heme cytochrome P450 (the protein enzyme).
Letrozole vs Other Aromatase Inhibitors
Letrozole, unlike Aromasin (Exemestane), is not a suicidal aromatase inhibitor. It’s not going to permanently disable the aromatase enzyme. Instead, Letrozole is definitely more powerful than both Aromasin (Exemestane) and Arimidex (Anastrozole).
Femara – Letrozole In Bodybuilding
Considering that Letrozole is the most powerful Aromatase Inhibitor in the world that does a great job in reducing estrogen levels really fast and drastically, it’s obvious that lots of bodybuilders found a way to use it. That’s because estrogen is a hormone that’s often causing issues when you introduce anabolic steroids. Since anabolic steroids are often increasing estrogen levels way high but Femara does a great job at lowering it – Letrozole in bodybuilding found its way.
This is a great weapon for dealing with emergency situations, for example, when estrogen is really high and the side effects related to this hormone are getting out of control. By introducing Letrozole, you’re dealing with this problem fast and efficiently.
Generally, it’s a great tool when you add aromatizing steroids that are converted into estrogens such as Dianabol, Deca Durabolin, Testosterone, Equipoise, and others. Using these steroids (especially stacked and/or in higher doses) can lead to an increase in estrogen way over the normal levels. This would obviously lead to various estrogenic side effects such as water retention, erectile dysfunction, gynecomastia (man’s boobs), high blood pressure, reduction in sleep quality and energy, and others.
Usually, most issues go away immediately if you lower estrogen in time. However, leaving estrogen high for a long period it could lead to possible permanent issues. Such as gynecomastia which would require invasive surgery to deal with.
Femara – Letrozole and Gynecomastia
In fact, that’s what most bodybuilders and steroid users run it for – gynecomastia treatment. That’s because when it comes to treating gynecomastia (known as bitch tits, or man’s boobs), there’s just nothing better than letrozole. This is the most effective thing for treating gyno. When it comes to treating gynecomastia, be sure there’s just nothing more effective. So, this is the aromatase inhibitor that could help you avoid surgery when talking about gynecomastia.
According to studies, Letrozole is able to destroy breast tissue tumors completely. This indicates how immensely effective Femara is for treating gynecomastia.
So, if you find yourself developing gynecomastia and there’s nothing that can help, Letrozole is your best bet. Remember it lowers total estrogen levels quickly and sharply.
Letrozole Side Effects
If you’ve been using anabolic steroids then you know that everything you do, you should do it carefully. By using too much of something that’s likely to cause side effects. Be sure that’s true about Letrozole too.
For example, by using too much Femara, it’s going to lower estrogen extremely high. And while you may think that this is a female hormone and you don’t need it, that’s a huge mistake. Estrogen is actually helping males grow muscles and it has numerous other functions.
Using too much Letrozole dosage and/or for too long periods is going to lead to not enough estrogen levels. Estrogen is a hormone that can affect your mood and has an important role in your immune system, libido and erection, muscle and strength, bone health, cholesterol health, and so on and so forth. You may end up with a lot of nasty side effects by using Letrozole too much!
And considering this is an immensely powerful aromatase inhibitor, that’s very likely to occur. That’s why you have to be extremely careful with Femara (letrozole) and make sure you do not abuse it in any way or form.
- I recommend keeping it handy for emergency situations, especially if you’re prone to estrogen issues and gynecomastia. But it’s better to start off with milder aromatase inhibitors (AIs) and even if you use Letrozole- do it wisely.
Letrozole Dosage
Letrozole is coming in the form of oral tablets of 2.5 mg tablets and dosages are very low. Especially for bodybuilding purposes. They generally range between 1.25 mg to 2.5 mg taken as needed. It could be once a week, or once a day. It depends on how you respond to it, your goals, and so on and so forth.
Femara has a rather long half life of about 2-4 days. That’s why it could last for a long period after a single dosage. That’s why do not be too impulsive. It’s a great idea to start with conservative dosages and only increase if you think you need higher doses. I have to warn you that an overdose of this anabolic steroid can lead to some really harsh side effects!
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