Nolvadex FAQ

What is Nolvadex?

Nolvadex is the brand name for Tamoxifen Citrate – a medication that is medically used to treat and prevent breast cancer. This is a Selective Estrogen Receptor Modulator (SERM) type of drug, meaning it blocks estrogen receptors in specific tissues of the body. For example, in the breast tissue, it blocks estrogen activity, which prevents and treats breast cancers that rely on estrogen to grow. But Nolvadex is also very popular in bodybuilding, during and/or after a steroid cycle. Steroid users run it for Post Cycle Therapy (PCT) to restore natural testosterone production after the use of steroids suppressed it. And to prevent or treat early-stage gynecomastia. Some steroids increase estrogen levels, and this extra estrogen can cause gynecomastia. Tamoxifen blocks estrogen receptors in breast tissues, helping prevent or reduce gyno symptoms. It also stimulates the pituitary gland to produce hormones that help the testicles produce more natural testosterone.

How much Nolvadex for PCT?

Nolvadex dosage for PCT is usually started at 40 mg per day for the first 2 weeks of the PCT protocol, to kickstart the natural testosterone production. Then you lower the dosage to 20 mg per day for the last 2 weeks of the PCT plan. This dosage is enough to help support the recovery of natural testosterone, but it is lower to stay away from possible side effects. The Post Cycle Therapy (PCT) protocol usually lasts 4 weeks, but some go for a 5-6 week length if the suppression is harsher (such as from harsher cycles). Usually, they taper further, such as 10-20 mg/day for week 5 and 10 mg/day for week 6. You start taking Tamoxifen when all steroids are out of the system. About one week with short-ester steroids, and 2 weeks with longer-ester steroids. Nolvadex often stacks with Clomid for PCT.

What does Nolvadex do?

Nolvadex (tamoxifen) is a Selective Estrogen Receptor Modulator (SERM) type of drug. This means that it selectively binds to estrogen receptors in certain tissues, blocking estrogen from binding to those receptors, exerting its effects. This means that it blocks estrogen from working in certain tissues, mainly in breast tissues and brain tissues (hypothalamus). It will not lower total estrogen levels in a way that aromatase inhibitors (AIs) do. Tamoxin blocks estrogen from reaching the receptors in the breasts, preventing or treating gynecomastia in bodybuilding, or breast cancer in medicine. It also blocks estrogen from reaching the hypothalamus (in the brain). This causes it to release more GnRH – a hormone that stimulates the pituitary gland to release more LH and FSH – hormones that signal the testicles to produce more testosterone. That’s how it helps restore normal hormone function after a steroid cycle during the Post Cycle Therapy (PCT).

Does Nolvadex boost testosterone?

Yes, Nolvadex (tamoxifen) can boost testosterone levels. However, it will not directly increase testosterone levels, such as an actual exogenous testosterone injection can. It will indirectly increase testosterone levels by tricking your body into thinking estrogen levels are low. The body tries to maintain a proper balance of hormones, and since tamoxifen blocks estrogen receptors in the hypothalamus and pituitary gland, the body thinks that estrogen levels are low. It needs more testosterone to convert into estrogen, bringing estrogen to normal levels. That’s why it starts a process that helps the body produce more testosterone. For example, the hypothalamus releases more GnRH, which triggers the pituitary gland to release more LH and FSH. These are crucial hormones signaling the testicles to produce more testosterone. That’s why Nolvadex (tamoxifen) is an important product for Post Cycle Therapy (PCT) to help kickstart the body’s natural testosterone production after suppression from anabolic steroids.

Does Nolvadex increase testosterone?

Yes, Nolvadex (tamoxifen) does increase testosterone, but only in certain cases. For example, it significantly helps men whose natural testosterone production has been suppressed after a steroid cycle or in cases of secondary hypogonadism (where the problem is in the brain, not the testicles themselves). Tamoxifen will not directly create testosterone. However, it will stimulate the body to make more of it on its own, by working on the brain and the hormonal system. This is the reason why Nolvadex does NOT build muscle directly, and it is not a performance enhancer. It is a recovery tool; it can’t be used as a cycle for physique and performance enhancement. It is also NOT going to work well in case your testosterone levels are low for reasons other than suppression. Such as for primary hypogonadism, where the testes themselves are damaged or non-functional. But it can still help boost testosterone naturally.

Does Nolvadex lower estrogen?

No, Nolvadex (tamoxifen) does not lower estrogen levels. It is an anti-estrogen, similar to Aromatase Inhibitors (AIs) that block aromatase enzymes from converting androgens (such as testosterone) into estrogen, lowering overall estrogen levels in the body. However, it is an anti-estrogen because it is a Selective Estrogen Receptor Modulator (SERM), which works in completely different ways than AIs. For example, Tamoxifen binds to estrogen receptors, blocking estrogen from binding to receptors in certain parts of the body. However, the actual amount of estrogen in your blood stays the same. Instead of lowering estrogen, it blocks estrogen in the hypothalamus and breast tissue receptors. This helps prevent or reverse gynecomastia or breast cancer that requires estrogen to grow. And your brain thinks estrogen is low, releasing more LH and FSH, making your testes produce more testosterone.

What is Nolvadex used for?

Nolvadex (brand Tamoxifen) is used for a variety of things, depending on the context. For example, tamoxifen is common in medical settings to treat or prevent breast cancer that requires estrogen to form and grow in both women and men. But doctors occasionally may prescribe it to women for infertility treatment to induce ovulation, or to men for infertility treatment to boost natural testosterone production and sperm production. Sometimes, doctors may prescribe it off-label for men as a mild testosterone booster with secondary hypogonadism, or for gynecomastia prevention or treatment. Steroid users also use it for gynecomastia prevention or treatment, because some steroids boost estrogen levels, which increase the chances of gyno. In bodybuilding and performance enhancement purposes, it is so helpful as a Post Cycle Therapy (PCT) medication to help restore natural testosterone production, by stimulating LH and FSH, after it has been suppressed by the use of steroids.

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How long does Nolvadex take to kick in?

Nolvadex (tamoxifen) kicks in pretty quickly. However, how fast it will start working depends on why you’re using it, the dosage you use, and your personal response to the compound. For example, if you use it for Post Cycle Therapy (PCT) to recover natural testosterone production, it usually starts working within a few days, about 2 to 5 days. Full recovery takes 4 to 6 weeks, but noticeable improvements occur within the first 1 to 2 weeks. For gynecomastia symptoms, it takes 1 to 2 weeks for tenderness or puffiness to start disappearing, maybe even faster if gyno is caught early. However, Tamoxifen won’t do much for fully developed hard lumps (long term gyno). In bloodwork, LH/FSH/testosterone will increase within a week. Remember though, therapeutic effects are gradual. For breast cancer, improvements may occur within a few weeks, but it may take months for some results.

How to take Nolvadex PCT?

You start taking Nolvadex (tamoxifen) for PCT when all steroids are out of your system. That’s a few days for orals-only, up to one week after the last dosage of short-based steroids (such as Propionate, Acetate, Phenylpropionate esters), or about two weeks after the last dosage of long-based steroids (such as Enanthate, Cypionate, or Decanoate esters). The most common PCT protocol is 4 weeks, but optionally, you may extend to 6, and sometimes even 8 weeks, if the suppression is pretty harsh. Commonly, PCT protocols with Nolvadex stack with Clomid, but that’s optional. Sometimes even AIs and/or HCG. Usually, you kickstart Nolvadex PCT with a higher dosage of 40 mg/day for the first 2 weeks, then taper down to 20 mg/day for the next 2 weeks, and may taper even lower if using lower PCT protocols. Take it at the same time each day.

Is Nolvadex an AI?

No, Nolvadex (tamoxifen) is not an AI (Aromatase Inhibitor). It is actually a SERM (Selective Estrogen Receptor Modulator). While both AIs and SERMs are anti-estrogen type of medications, because both deal with high-estrogen symptoms, their mechanisms of action are completely different from one another. SERMs like tamoxifen and clomiphene block estrogen receptors in specific tissues such as the breast tissues or the hypothalamus. AIs like anastrozole and exemestane block the aromatase enzyme from aromatizing androgens into estrogens. They prevent estrogen from being produced in the first place. That’s why SERMs will not lower total estrogen levels in the body, unlike AIs. They only block estrogen from acting in certain areas. Both are helpful in bodybuilding, both are used during a steroid cycle and/or after a steroid cycle during Post Cycle Therapy (PCT). But they have certain differences, with different results.

What is Nolvadex used for in bodybuilding?

In bodybuilding, Nolvadex (tamoxifen) is mainly used for two different things. Post Cycle Therapy (PCT) to restore natural testosterone production, and gynecomastia treatment or prevention. It may be used for boosting sperm count, treating infertility in men, but it is not as popular as Clomid (Clomiphene) for such purposes. It helps with PCT after running a steroid cycle because it kickstarts the body’s natural hormone production by boosting LH and FSH. These hormones tell your testicles to make more testosterone and sperm. It also helps with treating or preventing early gyno symptoms by blocking estrogen receptors in breast tissues, whenever gyno signs may show. Yet, it will not lower estrogen levels and may not deal with other high-estrogen symptoms. It is also not going to directly help build muscle or improve performance.

When to take Nolvadex during cycle?

It is important to understand that taking Nolvadex during a cycle is not always needed in the first place. During the cycle, it is only used to prevent or treat gynecomastia. For Post Cycle Therapy (PCT), you start to use it when all steroids are out of your body. You need to wait a while for steroids to flush out. That’s when the body restarts the recovery process, and Tamoxifen can help. So, during the cycle, you only use it to prevent or treat gynecomastia. But it is not always necessary because using steroids does not guarantee you will experience gyno. Some people do not. You need to use Nolvadex during the cycle only if you’re running aromatizable compounds. Like testosterone, Dianabol, Deca, and others (especially in higher doses). And you start noticing early gyno signs. Such as puffy nipples, itchy/sensitive chest, lump formation, or swelling in the nipple area.

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